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KMID : 1377020160130030270
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Tissue Engineering and Regenerative Medicine
2016 Volume.13 No. 3 p.270 ~ p.273
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Effects of estrogen on intracellular calcium-related T-lymphocyte function
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Kim Yoon-Young
Kim Hoon
Ku Seung-Yup
Suh Chang-Suk
Kim Seok-Hyun
Choi Young-Min
Kim Sung-Joon
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Abstract
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Regulation of immune cell function is an important in the field of hormone-related tissue engineering and regenerative medicine. In this sense, hormonal regulation of immune cell function is a critical issue to be solved. It has been known that ovarian sex hormone play an important roles in immune function, however, little has been known whether estrogen affects T-lymphocyte function. Human Jurkat T cells were treated with estradiol (E2) at concentrations of 0, 10, 100, 1000 ng/mL, and calcium response was evaluated. Intracellular calcium concentrations after Fura-2 acetoxymethyl ester treatment show an increasing trend at higher E2 concentrations although these alterations did not reach a statistical significance. The expression of calcium channel-related gene CACNA1C did not show any significant changes according to the concentration of E2. Taken together, estrogen has an implication as a possible hormonal regulator of intracellular calcium release in human Jurkat T cells via non-genomic pathway. Further studies are necessary to investigate the combined effects of sex hormones and cytokines in both T- and B-lymphocytes.
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KEYWORD
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Estrogen, T-lymphocyte, Calcium channel
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